Failures in Temporal Lobe Epilepsy Surgery

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چکیده

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Temporal Lobe Epilepsy Surgery Failures: A Review

Patients with temporal lobe epilepsy (TLE) are refractory to antiepileptic drugs in about 30% of cases. Surgical treatment has been shown to be beneficial for the selected patients but fails to provide a seizure-free outcome in 20-30% of TLE patients. Several reasons have been identified to explain these surgical failures. This paper will address the five most common causes of TLE surgery failu...

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P8: Temporal Lobe Epilepsy and Mitochondrial Dysfunction

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The Determiners of Temporal Lobe Epilepsy Surgery Outcome in a Developing Country

Background: Epilepsy surgery has become a successful treatment option for patients with drug-resistant epilepsies. Objectives: This study aimed to assess temporal lobe epilepsy (TLE) surgery outcome and its association with epilepsy duration, the presence of pre-surgical generalized tonic-clonic seizure (GTCS), and brain MRI findings. Materials & Methods: This retrospective study was perfo...

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Reply: Temporal plus epilepsy is a major determinant of temporal lobe surgery failures.

Reasons for failed temporal lobe epilepsy surgery remain unclear. Temporal plus epilepsy, characterized by a primary temporal lobe epileptogenic zone extending to neighboured regions, might account for a yet unknown proportion of these failures. In this study all patients from two epilepsy surgery programmes who fulfilled the following criteria were included: (i) operated from an anterior tempo...

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Brain Atrophy Following Temporal Lobe Epilepsy Surgery

Introduction Current understanding of the secondary effects of brain surgery, both conventional and irradiative, is largely limited to clinical observations. Studies of post-operative imaging data have mainly concentrated on brain atrophy following radiotherapy and/or chemotherapy [ 1,2]. We have investigated the effect of conventional surgery on the unresected brain tissue based on the compari...

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ژورنال

عنوان ژورنال: Neurosurgery

سال: 2014

ISSN: 0148-396X

DOI: 10.1227/neu.0000000000000209